منابع مشابه
Learning Precisely Timed Spikes
To signal the onset of salient sensory features or execute well-timed motor sequences, neuronal circuits must transform streams of incoming spike trains into precisely timed firing. To address the efficiency and fidelity with which neurons can perform such computations, we developed a theory to characterize the capacity of feedforward networks to generate desired spike sequences. We find the ma...
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The NMDA spike is a long-lasting nonlinear phenomenon initiated locally in the dendritic branches of a variety of cortical neurons. It plays a key role in synaptic plasticity and in single-neuron computations. Combining dynamic system theory and computational approaches, we now explore how the timing of synaptic inhibition affects the NMDA spike and its associated membrane current. When impingi...
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Mitral cells, the principal cells of the olfactory bulb, respond to sensory stimulation with precisely timed patterns of action potentials. By contrast, the same neurons generate intermittent spike clusters with variable timing in response to simple step depolarizations. We made whole cell recordings from mitral cells in rat olfactory bulb slices to examine the mechanisms by which normal sensor...
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ژورنال
عنوان ژورنال: Nature
سال: 2012
ISSN: 0028-0836,1476-4687
DOI: 10.1038/481446a